凤丹籽饼粕中一个新单萜苷

刘普, 卢宗元, 邓瑞雪, 李亮, 尹卫平*

中国药学杂志 ›› 2014, Vol. 49 ›› Issue (5) : 360-362.

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中国药学杂志 ›› 2014, Vol. 49 ›› Issue (5) : 360-362. DOI: 10.11669/cpj.2014.05.003
论 著

凤丹籽饼粕中一个新单萜苷

  • 刘普, 卢宗元, 邓瑞雪, 李亮, 尹卫平*
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A New Monoterpene Glycoside Isolated from Seed Cake of Paeonia ostii

  • LIU Pu, LU Zong-yuan, DENG Rui-xue, LI Liang, YIN Wei-ping*
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摘要

目的 研究凤丹籽饼粕的化学成分。方法 采用硅胶、凝胶柱色谱及制备高效液相色谱等多种色谱分离方法对凤丹籽饼粕醇提取物的正丁醇部位分离、纯化, 根据波谱数据分析鉴定化合物结构。结果 从牡丹籽饼粕的正丁醇部位分离得到3个化合物, 分别鉴定为4, 9-二羟基-8-10-去氢百里香酚-1-O-β-D-葡萄糖苷(4, 9-dihydroxy-8, 10-dehydrothymol-1-O-β-D-glucoside, 1), 6′-O-β-D-葡萄糖白芍苷(6′-O-β-D-glucopyranosylalbiflorin, 2), paeonidanin(3)。结论 化合物1为新化合物, 化合物2和3为首次从凤丹种子及凤丹中分离得到的化合物。

Abstract

OBJECTIVE To study the chemical constituents from the seed cake of Paeonia ostii. METHODS Chemical constituents were isolated by Sephadex LH-20, preparative HPLC, and silica gel column chromatography. The structures were elucidated on the basis of spectral data analysis. RESULTS Three compounds, 4, 9-dihydroxy-8, 10-dehydrothymol-1-O-β-D-glucoside(1), 6′-O-β-D-glucopyranosylalbiflorin(2), and paeonidanin(3), were isolated from the seed cake of P. ostii. CONCLUSION Compound 1 is a new compound, and compounds 2 and 3 were isolated from the seed cake of P. ostii for the first time.

关键词

凤丹 / 籽饼粕 / 4 / 9-二羟基-8-10-去氢百里香酚-1-O-β-D-葡萄糖苷 / 6′-O-β-D-葡萄糖白芍苷 / paeonidanin / 化学成分 / 单萜苷

Key words

Paeonia ostii / seed cake / 4, 9-dihydroxy-8, 10-dehydrothymol-1-O-β-D-glucoside / 6′-O-β-D-glucopyranosylalbiflorin / paeonidanin / chemical constituent / monoterpene glycoside

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刘普, 卢宗元, 邓瑞雪, 李亮, 尹卫平*. 凤丹籽饼粕中一个新单萜苷[J]. 中国药学杂志, 2014, 49(5): 360-362 https://doi.org/10.11669/cpj.2014.05.003
LIU Pu, LU Zong-yuan, DENG Rui-xue, LI Liang, YIN Wei-ping*. A New Monoterpene Glycoside Isolated from Seed Cake of Paeonia ostii[J]. Chinese Pharmaceutical Journal, 2014, 49(5): 360-362 https://doi.org/10.11669/cpj.2014.05.003
中图分类号: R284   

参考文献

QI J C, ZHOU H M, MA J Q, et al. Analysis of the chemical constituents in Peony seed oil by GC-MS. Cereals Oils(粮食与油脂), 2005, 19(11):22-23. SATYAJIT D S, PENSRI W, LAURENCE D, et al. Identification and ecdysteroid antagonist activity of three resveratrol trimers(Suffruticosols A, B and C) from Paeonia suffruticosa. Tetrahedron, 1999, 55(2):513-524. HE C N, XIAO W, XIAO P G, et al. Chemical constituents from seeds of Paeonia suffruticosa. China J Chin Mater Med(中国中药杂志), 2010, 35(11):1428-1431. HE C N, ZHANG Y C, XIAO P G, et al. Monoterpene glycosides from the seeds of Paeonia suffruticosa protect HEK 293 cells from irradiation-induced DNA damage. Phytochemistry Letters, 2012, 5(1):128-133. YI J P, ZHU W X, MA H L, et al. Studies on chemical constituents from seeds of Paeonia suffruticosa Andr. Nat Prod Res Dev(天然产物研究与开发), 2009, 20(21):604-607. LIU P, DENG R X, et al. Monoteroene Glucosides in seed of Paeonia ostill. Chin Pharm J(中国药学杂志), 2013, 48(17):1445-1448. FENG G, ZHANG J, BAI J, et al. Isolation and identification of acaricidal composition of Thymus mongolicus. Acta Bot Boreal Occident Sin(西北植物学报), 2009, 29(9):1893-1897. PHAM H Y, PHAM V K, NGUYEN X N, et al. A new monoterpene glycoside from the roots of Paeonia lactiflora increases the differentiation of osteoblastic MC3T3-E1 cells. Arch Pharm Res, 2007, 30(10):1179-1185. MAMORU O, YOSHIKI K, OLIMJON K. et al. Monoterpene glycosides from Paeonia hybrida. Phytochemistry, 2008, 69(8):1767-1772.

基金

河南科技大学自然科学领域创新能力培育基金资助项目(2012ZCX005)
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